While there won't be a Collector's Edition of Fable III on PC, "we're making sure that digital content from the Xbox 360 LCE version will be available for download for PC players." All the post-release downloadable content for the Xbox 360 version will also be available to owners of the PC game.
If you're sitting there wondering whether you might not want to check out Fable III because you missed its predecessor, Molyneux says that shouldn't be an issue. "Yes I can understand your concern but I should stress that although Fable has become a series, we create every iteration as we would develop any Lionhead game, as a standalone entity. Fable III will be a very different experience from Fable II and I honestly don't think that PC gamers will be in any way disadvantaged by not having played Fable II. In much the same way that any Xbox 360 gamer will be able to jump right into Fable III without having played either of the earlier games."
Though you don't really hear this feature talked about much since the days of Shadowrun and Halo 2 PC, Molyneux also confirmed that there'll be no cross-platform play with Fable III. On the subject of support for Project Natal, the Xbox 360 motion sensing camera, Molyneux stated, "Project Natal has been developed specifically for Xbox 360 so it's just not possible to include Project Natal features in a PC version."
I too am also glad Natal will be absent from the PC release, this alone makes me more inclined to just get Fable 3 for PC now. Cheers for the rep btw m8 
Much appreciated ! 
